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CMPPE

Cat. No. M8579

All AbMole products are for research use only, cannot be used for human consumption.

CMPPE Structure

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Biological Activity

CMPPE is a GABAB receptor positive allosteric modulator (PAM). GABAB receptor positive allosteric modulators have potential for treatment of many neuro-psychiatric disorders as well as drug dependence and seizures. The receptor is a GPCR expressed throughout the CNS; it acts as both an auto-receptor and heteroreceptor to mudulate GABA release and regulate K+ channels and Ca++ channels. CMPPE has the highest hypoactivity/anticonvulsant ratio.

Chemical Information
Molecular Weight 370.88
Formula C20H23ClN4O
CAS Number 841253-81-4
Solubility (25°C) DMSO: 5 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Paola Maccioni, et al. Suppressing effect of CMPPE, a new positive allosteric modulator of the GABA B receptor, on alcohol self-administration and reinstatement of alcohol seeking in rats

[2] Valentina Vengeliene, et al. Efficacy and side effects of baclofen and the novel GABA B receptor positive allosteric modulator CMPPE in animal models for alcohol and cocaine addiction

[3] Jordan W Brown, et al. Anticonvulsant effects of structurally diverse GABA(B) positive allosteric modulators in the DBA/2J audiogenic seizure test: Comparison to baclofen and utility as a pharmacodynamic screening model

[4] Elisabetta Perdona', et al. In vitro and in vivo characterization of the novel GABAB receptor positive allosteric modulator, 2-{1-[2-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-2-piperidinyl}ethanol (CMPPE)

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