Free shipping on all orders over $ 500

CM-272

Cat. No. M9442
CM-272 Structure
Synonym:

CM272

Size Price Availability Quantity
5mg USD 200 In stock
10mg USD 350 In stock
50mg USD 800 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

CM-272 is a first-in-class reversible dual small molecule inhibitor against G9a and DNMTs in hematological malignancies. CM-272 inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP with IC50s of 8 nM, 382 nM, 85 nM, 1200nM and 2 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 478.63
Formula C28H38N4O3
CAS Number 1846570-31-7
Purity >98%
Solubility DMSO
saline
Storage at -20°C
References

Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies.
San Jose-Eneriz E, et al. Nat Commun. 2017 May 26;8:15424. PMID: 28548080.

Related Histone Methyltransferase Products
PFI-2 hydrochloride

PFI-2 hydrochloride is a potent, highly selective and cell-active inhibitor of the methyltransferase activity of SETD7, with IC50 of 2 nM.

GSK3326595

GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 6.2 nM.

MI-503

MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM.

MI-463

MI-463 is a highly potent and orally bioavailable small molecule inhibitor of the Menin-MLL interaction, with an IC50 value of 15.3 nM.

MI-2

MI-2 (Menin-MLL Inhibitor 2) is a potent menin-MLL interaction inhibitor with IC50 of 446±28 nM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: CM-272, CM272 supplier, Histone Methyltransferase, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.