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CM-272

Cat. No. M9442
CM-272 Structure
Synonym:

CM272

Size Price Availability Quantity
5mg USD 200  USD200 In stock
10mg USD 350  USD350 In stock
50mg USD 800  USD800 In stock
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Quality Control
Biological Activity

CM-272 is a first-in-class reversible dual small molecule inhibitor against G9a and DNMTs in hematological malignancies. CM-272 inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP with IC50s of 8 nM, 382 nM, 85 nM, 1200nM and 2 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 478.63
Formula C28H38N4O3
CAS Number 1846570-31-7
Purity >98%
Solubility DMSO
saline
Storage at -20°C
References

[1] San Jose-Eneriz E, et al. Nat Commun. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: CM-272, CM272 supplier, Histone Methyltransferase, inhibitors

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