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CLP257 is a selective K+-Cl− cotransporter KCC2 activator that restored impaired Cl− transport in neurons with reduced KCC2 activity. Apparently, CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally.
| Molecular Weight | 307.34 |
| Formula | C14H14FN3O2S |
| CAS Number | 1181081-71-9 |
| Solubility (25°C) | DMSO: 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Francesco Ferrini, et al. Enhancing KCC2 function counteracts morphine-induced hyperalgesia
[5] Shabnam Hamidi, et al. KCC2 function modulates in vitro ictogenesis
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