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Clozapine N-oxide

Cat. No. M7684
Clozapine N-oxide Structure
Synonym:

CNO

Size Price Availability Quantity
5mg USD 72 In stock
10mg USD 108 In stock
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Biological Activity

Clozapine N-oxide (CNO) is a 5-HT2 serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.

In vivo, after a single intraperitoneal (i.p.) injection of Clozapine N-oxide (1 mg/kg) into mice, Clozapine N-oxide (CNO) plasma levels peak at 15 min and are very low after 2 h. Acutely administered CNO can be metabolically converted to Clozapine in other species such as human and guinea-pig.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 342.82
Formula C18H19ClN4O
CAS Number 34233-69-7
Purity 99.87%
Solubility DMSO 10 mM
Storage at -20°C
References

Novel designer receptors to probe GPCR signaling and physiology.
Wess J, et al. Trends Pharmacol Sci. 2013 Jul;34(7):385-92. PMID: 23769625.

Reversible metabolism of clozapine and clozapine N-oxide in schizophrenic patients.
Chang WH, et al. Prog Neuropsychopharmacol Biol Psychiatry. 1998 Jul;22(5):723-39. PMID: 9723115.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Clozapine N-oxide, CNO supplier, 5-HT Receptor, inhibitors

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