Clozapine N-oxide (CNO) is a 5-HT2 serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.
In vivo, after a single intraperitoneal (i.p.) injection of Clozapine N-oxide (1 mg/kg) into mice, Clozapine N-oxide (CNO) plasma levels peak at 15 min and are very low after 2 h. Acutely administered CNO can be metabolically converted to Clozapine in other species such as human and guinea-pig.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 10 mM|
Novel designer receptors to probe GPCR signaling and physiology.
Wess J, et al. Trends Pharmacol Sci. 2013 Jul;34(7):385-92. PMID: 23769625.
Reversible metabolism of clozapine and clozapine N-oxide in schizophrenic patients.
Chang WH, et al. Prog Neuropsychopharmacol Biol Psychiatry. 1998 Jul;22(5):723-39. PMID: 9723115.
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