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Clonidine

Cat. No. M13890
Clonidine Structure
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Clonidine is an alpha 2-adrenergic agonist.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 230.09
Formula
CAS Number 4205-90-7
Purity >99%
Solubility DMSO 90 mg/mL
Storage 2-8°C, protect from light
References

[1] Vonya N Streetz, et al. Role of Clonidine in Neonatal Abstinence Syndrome: A Systematic Review

[2] S G Gourlay, et al. Clonidine for smoking cessation

[3] M C Houston. Clonidine hydrochloride

[4] J L Gonzlez Machado, et al. [Clonidine and anesthesia]

[5] E N Vol'gram, et al. [Clonidine poisoning]

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