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Cladribine

Cat. No. M5524

Cladribine Structure

Synonym: 2-CdA, 2-chlorodeoxyadenosine

Size Price Availability Quantity
10mg USD 70 In stock
50mg USD 100 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Cladribine is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 285.69
Formula C10H12ClN5O3
CAS Number 4291-63-8
Purity >98%
Solubility 57 mg/mL in DMSO
Storage at -20°C
References

Cladribine Analogues via O⁶-(Benzotriazolyl) Derivatives of Guanine Nucleosides.
Satishkumar S, et al. Molecules. 2015 Oct 9;20(10):18437-63. PMID: 26473811.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Cladribine, 2-CdA, 2-chlorodeoxyadenosine supplier, DNA/RNA Synthesis, inhibitors

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