Ciprofloxacin hydrochloride is a β-diketone antibiotic with a broad spectrum antibacterial activity. Ciprofloxacin is an inhibitor of bacterial DNA gyrase (a subclass of Type II topoisomerases).
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||Water 60 mg/mL|
|Storage||2-8°C, dry, sealed|
Ciprofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use
D M Campoli-Richards, et al. Dгυgs. 1988 Apr;35(4):373-447. PMID: 3292209.
|Related Antibiotic Products|
Olanexidine is an antiseptic/disinfectant compound with potent bactericidal activity against Gram-negative and Gram-positive bacteria.
DIMBOA is a powerful antibiotic present in maize, wheat, and related grasses, possess growth inhibitory properties against many strains of studied bacteria and fungi, such as Staphylococcus aureus, Escherichia coli as well as against Saccharomyces cerevisiae.
|Tosufloxacin tosylate hydrate
Tosufloxacin tosylate hydrate is a fluoroquinolone antibacterial agent used to treat susceptible infections.
Tylosin is a macrolide antibiotic obtained from cultures of Streptomyces fradiae.
Cadazolid, a novel fluoroquinolone-oxazolidinone antibiotic, exhibits potent in vitro activity against Clostridium difficile, including the epidemic BI/NAP1/027 strain.
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