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Ciprofibrate

Cat. No. M2200
Ciprofibrate Structure
Size Price Availability Quantity
100mg USD 165 In stock
500mg USD 560 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Ciprofibrate is a peroxisome proliferator-activated receptor α (PPARα) agonist. Ciprofibrate belongs to the second generation of fibric acid derivatives. Ciprofibrate can induce proliferation of peroxisomes in liver cells of rats. Ciprofibrate treatment effectively reduced triglyceride-rich particles and non-HDL cholesterol, and significantly increased HDL cholesterol, proving its effectiveness in patients with low HDL cholesterol and type IV Frederickson's hyperlipidemia.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 289.15
Formula C13H14Cl2O3
CAS Number 52214-84-3
Purity >99%
Solubility DMSO 50 mg/mL
Ethanol 50 mg/mL
Storage at -20°C
References

Ciprofibrate treatment decreases non-high density lipoprotein cholesterol and triglycerides and increases high density lipoprotein cholesterol in patients with Frederickson type IV dyslipidemia phenotype.
Bermúdez-Pirela V, et al. Am J Ther. 2007 Mar-Apr;14(2):213-20. PMID: 17414592.

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