Free shipping on all orders over $ 500


Cat. No. M1690
CI-1040 Structure


Size Price Availability Quantity
10mg USD 90 In stock
50mg USD 280 In stock
200mg USD 650 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

CI-1040 (PD184352) is a targeted signal transduction inhibitor of MEK with a ki value of 300nM in vitro. CI-1040 (PD184352) is an orally active, highly specific, small-molecule inhibitor of one of the key components of this pathway (MEK1/MEK2), and thereby effectively blocks the phosphorylation of ERK and continued signal transduction through this pathway.

Customer Product Validations & Biological Datas
Source Antiviral Res (2017). Figure 2. CI-1040
Method in vitro investigations
Cell Lines Human lung epithelial cells
Concentrations 20 μM
Incubation Time 1 h
Results This export step is readily blocked in the presence of CI-1040 as evidenced by predominant nuclear staining of the viral NP, the major constituent of the RNPs, as well as the PB1 polymerase, which is associated with RNPs
Cell Experiment
Cell lines CCl39 cells expressing FLAG-ERK5
Preparation method Cells were serum-starved for 16 h prior to the addition of PD184352, or an equivalent of DMSO vehicle control for 90 min. Single dishes of cells were then stimulated with 10% FBS for 15 min and immune-complex kinase assays performed with either myelin basic protein (MBP; ERK1) or GST-MEF2C (ERK5), as a substrate. PD184352 inhibited FBS-induced ERK1 activation with an IC50 below 1 μM, whereas even a dose of 20 μM PD184352 was insufficient to inhibit ERK5 activity, induced in the same manner and assayed from the same cell extracts as ERK1.
Concentrations 0~1µM
Incubation time 90min
Animal Experiment
Animal models DBA/2-pcy/pcy mice
Formulation DMSO
Dosages 400 mg/kg daily for the first week and then every third day for 6 additional weeks
Administration Oral administration
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 478.67
Formula C17H14ClF2IN2O2
CAS Number 212631-79-3
Purity 98.81%
Solubility DMSO
Storage at -20°C

Inhibition of MEK pathway in vestibular schwannoma cell culture.
Neff et al. Laryngoscope. 2012 Aug 10. PMID: 22886786.

The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34+ CML stem/progenitor cells.
Pellicano et al. Leukemia. 2011 Jul;25(7):1159-67. PMID: 21483442.

Related MEK Products

RO4987655 is an orally active and highly selective MEK inhibitor with an IC50 of 5.2 nM.


BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively.


LY2801653 is a potent, orally bioavailable, small-molecule inhibitor of c-MET kinase(Ki= 2 nM).


Refametinib (BAY 86-9766, RDEA119) is a potent, highly selective and ATP non-competitive inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.


GDC-0973 is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase (MEK1/2).

Abmole Inhibitor Catalog 2017

Keywords: CI-1040, PD184352 supplier, MEK, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.