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Chrysophanol-8-O-β-D-glucopyranoside

Cat. No. M4326
Chrysophanol-8-O-β-D-glucopyranoside Structure
Size Price Availability Quantity
5mg USD 440  USD440 In stock
10mg USD 780  USD780 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Chrysophanol 8-O-glucoside is derived from the root of Rumex acetosa and has moderate elastase inhibitory activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 416.39
Formula C21H20O9
CAS Number 13241-28-6
Purity >98%
Solubility
Storage at -20°C
References

[1] Meichen Liu, et al. A Cell-Based Metabonomics Approach to Investigate the Varied Influences of Chrysophanol-8-O-β-D-Glucoside With Different Concentrations on L-02 Cells

[2] Cun Zhang, et al. Two new anthraquinone glycosides from the roots of Rheum palmatum

[3] Myung Sun Lee, et al. Anti-diabetic properties of chrysophanol and its glucoside from rhubarb rhizome

[4] Tran Minh Ngoc, et al. Lipoxygenase inhibitory constituents from rhubarb

[5] D H Kim, et al. Metabolism of rhaponticin and chrysophanol 8-o-beta-D-glucopyranoside from the rhizome of rheum undulatum by human intestinal bacteria and their anti-allergic actions

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