Free shipping on all orders over $ 500

Chlorotrianisene

Cat. No. M3692
Chlorotrianisene Structure
Synonym:

Chlortrianizen, Chlorotrianisine

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 36  USD40 In stock
100mg USD 63  USD70 In stock
500mg USD 189  USD210 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity 100.00%
  • COA
  • MSDS
Biological Activity

Chlorotrianisene is a non-steroidal synthetic estrogen that was formerly used for the treatment of menopause, deficiencies in ovary function, and prostate cancer. Chlorotrianisene may react vigorously with strong oxidizing agents. Can react exothermically with reducing agents (such as alkali metals and hydrides) to release gaseous hydrogen. Chlorotrianisene exhibits in vitro little or no binding to the uterine estrogen receptor (ER) but demonstrates potent estrogenic activity in vivo, indicating that Chlorotrianisene is a proestrogen/proantiestrogen. Chlorotrianisene could inhibit bone loss and delay the atrophy of uterus induced by ovariectomy in Wistar female rats. It has protective effects on bone like other estrogen preparations.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 380.86
Formula C23H21ClO3
CAS Number 569-57-3
Purity 100.00%
Solubility DMSO ≥ 50 mg/mL
Storage at -20°C
References

Prevention of bone loss by chlorotrianisene in oophorectomized rats.
Zhang J, et al. Zhonghua Fu Chan Ke Za Zhi. 1997 Sep;32(9):535-7. PMID: 9639753.

Monooxygenase-mediated activation of chlorotrianisene (TACE) in covalent binding to rat hepatic microsomal proteins.
Juedes MJ, et al. Drug Metab Dispos. 1987 Nov-Dec;15(6):786-93. PMID: 2893703.

Differential responses of pituitary kallikrein and prolactin to tamoxifen and chlorotrianisene.
Powers CA, et al. Mol Cell Endocrinol. 1989 Sep;66(1):93-100. PMID: 2583366.

Inactivation of the uterine estrogen receptor binding of estradiol during P-450 catalyzed metabolism of chlorotrianisene (TACE). Speculation that TACE antiestrogenic activity involves covalent binding to the estrogen receptor.
Kupfer D, et al. FEBS Lett. 1990 Feb 12;261(1):59-62. PMID: 2307235.

Related Estrogen Receptor Products
27-Hydroxycholesterol

27-Hydroxycholesterol is a selective estrogen receptor modulator, and it is also an agonist of the liver X receptor.

SAR439859 (Amcenestrant)

SAR439859 (Amcenestrant) is an orally active, nonsteroidal and selective degrader of estrogen receptor, it is also a potent antagonist of ER with EC50 of 0.2 nM for ERα degradation.

4-Hydroxytamoxifen

4-Hydroxytamoxifen is a selective estrogen receptor modulator.

Methylpiperidino pyrazole

Methylpiperidino pyrazole (MPP) is an agonist for estrogen receptor α and lacks any ligand functionality with estrogen receptor (ER)β.

Endoxifen E-isomer hydrochloride

Endoxifen E-isomer hydrochloride is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM).

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Chlorotrianisene, Chlortrianizen, Chlorotrianisine supplier, Estrogen Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.