Chlorambucil is an alkylating agent used in combination with prednisolone for the treatment of idiopathic membranous nephropathy. Chlorambucil significantly inhibites migration of EEC in Boyden chamber and wound healing experiments. The alkylating agent chlorambucil dramatically impairs directed cellular migration, which is accompanied by perturbations of cell polarity and mitochondrial membrane potential.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Chlorambucil-induced cytomegalovirus infection: a case report.
Lluva MT, et al. J Med Case Rep. 2014 Aug 20;8(1):280. PMID: 25142684.
Chlorambucil (nitrogen mustard) induced impairment of early vascular endothelial cell migration - Effects of α-linolenic acid and N-acetylcysteine.
Steinritz D, et al. Chem Biol Interact. 2014 Jun 2;219C:143-150. PMID: 24892517.
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