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Chlorambucil

Cat. No. M3661
Chlorambucil Structure
Synonym:

WR-139013, CB-1348

Size Price Availability
10mg USD 60 Out of stock
50mg USD 150 Out of stock
100mg USD 240 Out of stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Chlorambucil is an alkylating agent used in combination with prednisolone for the treatment of idiopathic membranous nephropathy. Chlorambucil significantly inhibites migration of EEC in Boyden chamber and wound healing experiments. The alkylating agent chlorambucil dramatically impairs directed cellular migration, which is accompanied by perturbations of cell polarity and mitochondrial membrane potential.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 304.21
Formula C14H19Cl2NO2
CAS Number 305-03-3
Purity >99%
Solubility DMSO
Storage at -20°C
References

Chlorambucil-induced cytomegalovirus infection: a case report.
Lluva MT, et al. J Med Case Rep. 2014 Aug 20;8(1):280. PMID: 25142684.

Chlorambucil (nitrogen mustard) induced impairment of early vascular endothelial cell migration - Effects of α-linolenic acid and N-acetylcysteine.
Steinritz D, et al. Chem Biol Interact. 2014 Jun 2;219C:143-150. PMID: 24892517.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Chlorambucil, WR-139013, CB-1348 supplier, DNA/RNA Synthesis, inhibitors

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