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Chebulinic acid

Cat. No. M9118
Chebulinic acid Structure
Synonym:

NSC69862

Size Price Availability Quantity
5mg USD 450 In stock
10mg USD 650 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity. Chebulinic acid reduce the expression and activity of MMP-2 at an ED50 value of 100 μM. Chebulinic acid significantly inhibited H+ K+-ATPase activity in vitrowith IC50 of 65.01 μg/ml.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 956.68
Formula C41H32O27
CAS Number 18942-26-2
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
References

Identification of chebulinic acid as potent natural inhibitor of M. tuberculosis DNA gyrase and molecular insights into its binding mode of action.
Patel K, et al. Comput Biol Chem. 2015 Dec;59 Pt A:37-47. PMID: 26410242.

Aqueous and alcoholic extracts of Triphala and their active compounds chebulagic acid and chebulinic acid prevented epithelial to mesenchymal transition in retinal pigment epithelial cells, by inhibiting SMAD-3 phosphorylation.
Sivasankar S, et al. PLoS One. 2015 Mar 20;10(3):e0120512. PMID: 25793924.

Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers.
Mishra V, et al. Phytomedicine. 2013 Apr 15;20(6):506-11. PMID: 23462212.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Chebulinic acid, NSC69862 supplier, DNA/RNA Synthesis, inhibitors

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