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Ceforanide

Cat. No. M8883
Ceforanide Structure
Size Price Availability
200mg USD 150 1-2 Weeks
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Ceforanide is a semi-synthetic, beta-lactam, broad-spectrum, second-generation cephalosporin antibiotic. It has bactericidal activity and is used in the sterilization in various medical procedures. Ceforanide causes inhibition of bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of the cell wall. Ceforanide has a longer elimination half-life than any currently available cephalosporin.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 519.55
Formula C20H21N7O6S2
CAS Number 60925-61-3
Purity >98%
Solubility DMSO 5 mg/mL (Slightly)
Aqueous Base (Slightly)
Storage at -20°C
References

Analytical investigation of beta-lactam antibiotics in pharmaceutical preparations. IX. Colorimetric determination of six cephalosporins of second and third generation in the range of micromolar concentrations.
Issopoulos PB, et al. Acta Pharm Hung. 1996 Mar;66(2):89-94. PMID: 8669283.

The in vitro activity of beta-lactamase inhibitors in combination with cephalosporins against M. tuberculosis.
Chen CH, et al. Proc Natl Sci Counc Repub China B. 1995 Apr;19(2):80-4. PMID: 7624446.

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  Catalog
Abmole Inhibitor Catalog 2017




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