Ceforanide is a semi-synthetic, beta-lactam, broad-spectrum, second-generation cephalosporin antibiotic. It has bactericidal activity and is used in the sterilization in various medical procedures. Ceforanide causes inhibition of bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of the cell wall. Ceforanide has a longer elimination half-life than any currently available cephalosporin.
| Molecular Weight | 519.55 |
| Formula | C20H21N7O6S2 |
| CAS Number | 60925-61-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 5 mg/mL (Slightly) Aqueous Base (Slightly) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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| Cefcapene pivoxil hydrochloride
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