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Caryolane-1,9β-diol

Cat. No. M17505
Caryolane-1,9β-diol Structure
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Biological Activity

Caryolane-1,9β-diol

Chemical Information
CAS Number 155485-76-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yong-Ming Yan, et al. J Ethnopharmacol. Anti-diabetic nephropathy compounds from Cinnamomum cassia

[2] Qiao-hui Zeng, et al. Food Funct. Isolation and identification of ingredients inducing cancer cell death from the seeds of Alpinia galanga, a Chinese spice

[3] Meng Shao, et al. Zhongguo Zhong Yao Za Zhi. [Chemical constituents of leaves of Psidium guajava]

[4] Jos Cludio D Aguiar, et al. Nat Prod Commun. Chemical constituents and larvicidal activity of Hymenaea courbaril fruit peel

[5] Huaxu Zhu, et al. Zhongguo Zhong Yao Za Zhi. [Bioactive constituents from whole herbs of Vernonia cinerea (II)]

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