Carteolol hydrochloride is a non-selective beta blocker. Carteolol hydrochloride at 1 mmol/L (P<0.05) significantly inhibites H2O2-induced cell damage and is able to scavenge O2 (EC50 value: 48 mmol/L). Carteolol hydrochloride has a protective action against UVB-induced HCEC damage, and its radical scavenging ability may be an important basis for this effect.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Carteolol hydrochloride protects human corneal epithelial cells from UVB-induced damage in vitro.
Kuwahara K, et al. Cornea. 2005 Mar;24(2):213-20. PMID: 15725891.
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