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Capecitabine

Cat. No. M1963

Capecitabine Structure

Synonym: Xeloda, Roche

Size Price Availability Quantity
100mg USD 50 In stock
1g USD 360 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Capecitabine is a novel oral fluoropyrimidine carbamate. Capecitabine is a prodrug, that is enzymatically converted to 5-fluorouracil in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. Capecitabine may inhibit cytochrome CYP2C9 enzyme, and therefore increase levels of substrates such as phenytoin and other substrates of CYP2C9. Capecitabine has shown varying degrees of efficacy with acceptable tolerability in numerous cancers including prostate, renal cell, ovarian, and pancreatic, with the largest amount of evidence in metastatic breast and colorectal cancer. After oral administration of 1250 mg/m2, capecitabine is rapidly and extensively absorbed from the gastrointestinal tract [with a time to reach peak concentration (tmax) of 2 hours and peak plasma compound concentration (Cmax) of 3 to 4 mg/L] and has a relatively short elimination half-life (t(1/2)) [0.55 to 0.89 h]. Capecitabine has been reported to increase serum phenytoin levels and the international normalized ratio in patients receiving concomitant phenytoin and warfarin, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 359.35
Formula C15H22FN3O6
CAS Number 154361-50-9
Purity >99%
Solubility DMSO 72 mg/mL
Ethanol 72 mg/mL
Storage at -20°C
References

Capecitabine: a review.
Walko CM, et al. Clin Ther. 2005 Jan;27(1):23-44. PMID: 15763604.

Clinical pharmacokinetics of capecitabine.
Reigner B, et al. Clin Pharmacokinet. 2001;40(2):85-104. PMID: 11286326.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Capecitabine, Xeloda, Roche supplier, DNA/RNA Synthesis, inhibitors

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