Candesartan (Atacand) is an angiotensin II receptor antagonist with an IC50 of 15 ug/kg. It reduced the risk of developing hypertension by nearly two-thirds during this period. In the last two years of the study, all participants were switched to placebo. By the end of the study, candesartan had significantly reduced the risk of hypertension, by more than 15%.
| Cell Experiment | |
|---|---|
| Cell lines | KU-19-19 cells |
| Preparation method | Seeding KU-19-19 cells at a cell density of 2 ×104 per well in 96-well plates and allowed to grow overnight. Then treating the cells with various concentrations of Candesartan for various periods of time. Cell viability is determined by the Alamar Blue assay to examine the cytotoxicity and antiproliferative effect of candesartan. Determining the absorbance value of each well in a microplate reade |
| Concentrations | 10 μM |
| Incubation time | 48 hours |
| Animal Experiment | |
|---|---|
| Animal models | Mouse KU-19-19 xenograft model |
| Formulation | Saline |
| Dosages | 10 mg/kg |
| Administration | Gavage |
| Molecular Weight | 440.45 |
| Formula | C24H20N6O3 |
| CAS Number | 139481-59-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Toni L Ripley, et al. Candesartan in heart failure
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