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Cabergoline

Cat. No. M5475
Cabergoline  Structure
Size Price Availability Quantity
5mg USD 110 In stock
10mg USD 200 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Cabergoline, an ergot derivative, is a potent dopamine receptor agonist on D2 receptors.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 451.6
Formula C26H37N5O2
CAS Number 81409-90-7
Purity >99%
Solubility 33 mg/mL in DMSO
Storage at -20°C
References

Current drug withdrawal strategy in prolactinoma patients treated with cabergoline: a systematic review and meta-analysis.
Hu J, et al. Pituitary. 2015 Oct;18(5):745-51. PMID: 25500765.

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  Catalog
Abmole Inhibitor Catalog 2017




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