C16-Ceramide is a natural small molecule activating p53 through the direct and selective binding.
| Molecular Weight | 537.9 |
| Formula | C34H67NO3 |
| CAS Number | 24696-26-2 |
| Form | Solid |
| Solubility (25°C) | Ethanol 20 mg/mL (warming and heat to 60°C) DMF 20 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | 4°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related p53 Products |
|---|
| SCH529074
SCH529074 is an orally active, potent activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53. |
| BAY 1892005
BAY 1892005, a p53 protein modulator, is active on p53 condensates and does not lead to mutant p53 reactivation. |
| FOXO4-DRI
FOXO4-DRI is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. |
| p53 (17-26)
p53 (17-26) is amino acids 17 to 26 fragment of p53. |
| Azurin p28 peptide
Azurin p28 peptide is a tumor-penetrated antitumor peptide. |
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