Bucillamine is an orally bioavailable endogenous derivative of the amino acid cysteine with potential antioxidant and anti-inflammatory activity. Upon oral administration, Bucillamine rapidly enters cells via the same pathway as cysteine, complementing the thiol groups in glutathione ( GSH ), thereby increasing intracellular GSH levels and GSH activity.GSH is an antioxidant that plays an important protective role in oxidative stress and injury.
| Molecular Weight | 223.31 |
| Formula | C7H13NO3S2 |
| CAS Number | 65002-17-7 |
| Form | Solid |
| Storage | 4°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Keitaro Nakamoto et al. J Gen Fam Med. Bucillamine-induced interstitial pneumonitis
[2] T Yanagishita et al. J Eur Acad Dermatol Venereol. Bucillamine-induced pemphigus vulgaris
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