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Bruceine E

Cat. No. M16524
Bruceine E Structure
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Biological Activity

Bruceine E

Chemical Information
CAS Number 21586-90-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Farahdina Man, et al. J Chromatogr B Analyt Technol Biomed Life Sci. HPLC-MS/MS method for bioavailability study of bruceines D & E in rat plasma

[2] Abdulwali Ablat, et al. BMC Complement Altern Med. Antidiabetic effects of Brucea javanica seeds in type 2 diabetic rats

[3] Jie-Qing Liu, et al. Arch Pharm Res. One new pregnane glycoside from the seeds of cultivated Brucea javanica

[4] Ajmi NoorShahida, et al. J Ethnopharmacol. Hypoglycemic effect of quassinoids from Brucea javanica (L.) Merr (Simaroubaceae) seeds

[5] J X Xie, et al. Yao Xue Xue Bao. [The chemical constituents of the Chinese drug "Yadanzi." I. Isolation and identification of daucosterol, brucein D and brucein E (author's transl)]

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