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Brompheniramine is a histamine H1 receptors antagonist. Brompheniramine also functions as a moderately effective anticholinergic agent, and is likely an antimuscarinic agent similar to other common antihistamines such as diphenhydramine. Brompheniramine is an antihistamine compound of the propylamine (alkylamine) class. Brompheniramine has antidepressant properties, inhibiting reuptake of the neurotransmitter serotonin.Brompheniramine also has analgesic-sparing (potentiating) effects on opioid analgesics, commonly reducing codeine, dihydrocodeine, and hydrocodone requirements by 10 to 35 percent. Brompheniramine is metabolised by cytochrome P450s.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Molecular Weight | 435.31 |
| Formula | C16H19BrN2.C4H4 |
| CAS Number | 980-71-2 |
| Purity | >98% |
| Solubility | DMSO |
| Storage | at -20°C |
| Related Histamine Receptor Products |
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| S 38093
S 38093 is an inverse agonist at histamine H3 receptors, displays a moderate affinity for rat, mouse and human H3 receptors with Ki of 8.8, 1.44 and 1.2µM, respectively. |
| Emedastine Difumarate
Emedastine Difumarate is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. |
| Meta-Fexofenadine
Fexofenadine is a nonsedating antihistamine drug which is indicated for treatment of seasonal allergic rhinitis. |
| Roxatidine Acetate HCl
Roxatidine Acetate HCl is a specific and competitive histamin H2-receptor antagonist, with IC50 of 3.2 μM, inhibits gastric acid secretion and ulcer formation. |
| Ranitidine HCl
Ranitidine is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers. |
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