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BRACO-19 trihydrochloride is a telomerase inhibitor (IC50 = 115 nM). BRACO-19 trihydrochloride inhibits expression of human telomerase reverse transcriptase (hTERT), induces cellular senescence and inhibits growth of uterine cancer cells in vitro. BRACO-19 trihydrochloride inhibits growth of uterine tumor xenografts in mice.
| Molecular Weight | 703.14 |
| Formula | C35H43N7O2.3HCl |
| CAS Number | 1177798-88-7 |
| Solubility (25°C) | DMSO 39 mg/mL Water 18 mg/mL |
| Storage | 4°C, dry, sealed |
| Related DNA/RNA Synthesis Products |
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| Dencatistat
Dencatistat (P115) is an inhibitor of Cytidine Triphosphate Synthase 1 (CTPS1) with an IC50 value of ≤ 0.1 μM. |
| Antipain dihydrochloride
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| Tetrahydrouridine
Tetrahydrouridine (THU) is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine. |
| Crisnatol
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| Caf1-IN-1
Caf1-IN-1 is inhibitor for ribonuclease Caf1 with an IC50 of 0.59 µM. Caf1-IN-1 is also a weak inhibitor for poly(A)-specific ribonuclease (PARN) with IC50 of 23.9 µM. |
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