Free shipping on all orders over $ 500

Bosentan

Cat. No. M2467

Bosentan Structure
Size Price Availability Quantity
100mg USD 120 In stock
1g USD 700 In stock
Bulk Inquiry?

Quality Control
Biological Activity

Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 551.61
Formula C27H29N5O6S
CAS Number 147536-97-8
Purity >99%
Solubility DMSO 90 mg/mL
Storage at -20°C
Related Endothelin Receptor Products
Ro-46-2005

Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM.

Bosentan Hydrate

Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.

Macitentan

Macitentan is an orally-active, tissue-targeting dual ET receptor antagonist.

Sitaxsentan sodium

Sitaxsentan (TBC-11251) is an orally active, highly selective antagonist of endothelin A receptors.

Ambrisentan

Ambrisentan is an orally active, highly selective antagonist of the endothelin-1 type A receptor.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Bosentan supplier, Endothelin Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.