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BMS303141 blocks lipid synthesis (IC50 = 8 μM in HepG2 cells). Under identical incubation conditions, BMS-303141 showed no cytotoxicity up to 50 μM, indicating the observed inhibition of lipid synthesis was not a result of compound-induced cytotoxicity. BMS303141 Lowers plasma glucose and triglycerides in a mouse model of hyperlipidemia. BMS303141 is Orally bioavailable.
J Cell Mol Med. 2024 Mar;28(6):e18129.
SIRT2-mediated deacetylation of ACLY promotes the progression of oesophageal squamous cell carcinoma
BMS303141 purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | BALB/c nude mice (4‐5 weeks old) injected HepG2 cells |
| Formulation | saline |
| Dosages | 5 mg/kg/d for 8 days |
| Administration | gavage |
| Molecular Weight | 424.3 |
| Formula | C19H15Cl2NO4S |
| CAS Number | 943962-47-8 |
| Solubility (25°C) | DMSO ≥ 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Ma Z, et al. J Lipid Res. A novel direct homogeneous assay for ATP citrate lyase.
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