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BMS-191011

Cat. No. M9394
BMS-191011 Structure
Size Price Availability Quantity
5mg USD 60 In stock
10mg USD 90 In stock
50mg USD 358 In stock
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Quality Control
Biological Activity

BMS-191011 is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). BMS-191011 acts as a neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 370.71
Formula C16H10ClF3N2O3
CAS Number 202821-81-6
Purity >98%
Solubility DMSO ≥ 35 mg/mL
Storage at -20°C
References

3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR.
Romine JL, et al. J Med Chem. 2007 Feb 8;50(3):528-42. PMID: 17266205.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BMS-191011 supplier, Potassium Channel, inhibitors

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