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Blonanserin

Cat. No. M5466
Blonanserin Structure
Synonym:

AD 5423

Size Price Availability Quantity
25mg USD 90 In stock
100mg USD 220 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Blonanserin is a relatively selective serotonin (5-HT)2A and dopamine D2 antagonist, used the treatment of schizophrenia.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 367.5
Formula C23H30FN3
CAS Number 132810-10-7
Purity >98%
Solubility 10mM in DMSO
Storage at -20°C
References

Dopamine D3 receptor antagonism contributes to blonanserin-induced cortical dopamine and acetylcholine efflux and cognitive improvement.
Huang M, et al. Pharmacol Biochem Behav. 2015 Nov;138:49-57. PMID: 26383990.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Blonanserin, AD 5423 supplier, 5-HT Receptor, inhibitors

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