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Blasticidin S hydrochloride

Cat. No. M9163
Blasticidin S hydrochloride Structure
Synonym:

Bla-S; Blasticidin S; Blasticidin S HCl

Size Price Availability Quantity
10mg USD 150 In stock
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Quality Control
  • Current batch:
  • Purity >95%
  • COA
  • MSDS
Biological Activity

Blasticidin S HCl is a potent inhibitor of protein synthesis in both prokaryotic and eukaryotic cells. Blasticidin S Hydrochloride belongs to a group of cytosine amino nucleoside antibiotics. It has a wide spectrum of antimicrobial activity and acts on prokaryotic and eukaryotic organisms by inhibiting protein synthesis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 458.9
Formula C17H26N8O5.HCl
CAS Number 3513-03-9
Purity >95%
Solubility Water: ≥ 10 mg/mL
Storage at -20°C
References

Critical role of the proton-dependent oligopeptide transporter (POT) in the cellular uptake of the peptidyl nucleoside antibiotic, blasticidin S.
Kitamura K, et al. Biochim Biophys Acta Mol Cell Res. 2017 Feb;1864(2):393-398. PMID: 27916534.

Crystal and molecular structure of the antibiotic blasticidin S hydrochloride pentahydrate.
Swaminathan V, et al. Biochim Biophys Acta. 1981 Oct 27;655(3):335-41. PMID: 7284390.

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Keywords: Blasticidin S hydrochloride, Bla-S; Blasticidin S; Blasticidin S HCl supplier, Anti-infection, inhibitors

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