Free shipping on all orders over $ 500

Blasticidin S hydrochloride

Cat. No. M9163
Blasticidin S hydrochloride Structure
Synonym:

Bla-S; Blasticidin S; Blasticidin S HCl

Size Price Availability Quantity
10mg USD 120  USD120 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >95%
  • COA
  • MSDS
Biological Activity

Blasticidin S HCl is a potent inhibitor of protein synthesis in both prokaryotic and eukaryotic cells. Blasticidin S Hydrochloride belongs to a group of cytosine amino nucleoside antibiotics. It has a wide spectrum of antimicrobial activity and acts on prokaryotic and eukaryotic organisms by inhibiting protein synthesis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 458.9
Formula C17H26N8O5.HCl
CAS Number 3513-03-9
Purity >95%
Solubility Water: ≥ 10 mg/mL
Storage at -20°C
References

[1] Kitamura K, et al. Biochim Biophys Acta Mol Cell Res. Critical role of the proton-dependent oligopeptide transporter (POT) in the cellular uptake of the peptidyl nucleoside antibiotic, blasticidin S.

[2] Swaminathan V, et al. Biochim Biophys Acta. Crystal and molecular structure of the antibiotic blasticidin S hydrochloride pentahydrate.

Related Anti-infection Products
PF-07321332 (Nirmatrelvir)

PF-07321332 (Nirmatrelvir) is an orally bioavailable 3C-like protease (3CLPRO) inhibitor with an ki of 3.11 nM. PF-07321332 binds directly to the catalytic cysteine (Cys145) residue of the enzyme.

Indolicidin

Indolicidin is a potent antimicrobial peptide purified from the cytoplasmic granules of bovine neutrophils.

Tenuazonic acid

Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate.

ELQ-300

Elq-300 is an antimalarial drug available for biological research and is also an effective oral cytochrome BC1 complex (CYT BC1) reduction (Qi) site inhibitor.

MK-3118

MK-3118 is a novel glucan synthase inhibitor with activity against many echinocandin-resistant strains of Candida due to differential avidity for the target site compared to echinocandins.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Blasticidin S hydrochloride, Bla-S; Blasticidin S; Blasticidin S HCl supplier, Anti-infection, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.