Blasticidin S HCl is a potent inhibitor of protein synthesis in both prokaryotic and eukaryotic cells. Blasticidin S Hydrochloride belongs to a group of cytosine amino nucleoside antibiotics. It has a wide spectrum of antimicrobial activity and acts on prokaryotic and eukaryotic organisms by inhibiting protein synthesis.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||Water: ≥ 10 mg/mL|
Critical role of the proton-dependent oligopeptide transporter (POT) in the cellular uptake of the peptidyl nucleoside antibiotic, blasticidin S.
Kitamura K, et al. Biochim Biophys Acta Mol Cell Res. 2017 Feb;1864(2):393-398. PMID: 27916534.
Crystal and molecular structure of the antibiotic blasticidin S hydrochloride pentahydrate.
Swaminathan V, et al. Biochim Biophys Acta. 1981 Oct 27;655(3):335-41. PMID: 7284390.
|Related Anti-infection Products|
Ampicillin is an antibiotic against a variety of gram-positive and gram-negative bacteria.
Bedaquiline, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections.
Sodium Houttuyfonate is the active compound of the Houttuynia plant.
Thimerosal inhibits a wide range of thiol-dependent enzymes and proteins, such as PI3-kinase-dependent methionine synthetase, glutamate transport receptor, and Na++K+ dependence ATPase.
|Ac-CoA Synthase Inhibitor 1
Ac-CoA Synthase Inhibitor 1 (also known as ACSS2 Inhibitor), an anti-virus agent, is a Ac-CoA Synthase Inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.