Blasticidin S HCl is a potent inhibitor of protein synthesis in both prokaryotic and eukaryotic cells. Blasticidin S Hydrochloride belongs to a group of cytosine amino nucleoside antibiotics. It has a wide spectrum of antimicrobial activity and acts on prokaryotic and eukaryotic organisms by inhibiting protein synthesis.
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Molecular Weight | 458.9 |
Formula | C17H26N8O5.HCl |
CAS Number | 3513-03-9 |
Purity | >95% |
Solubility | Water: ≥ 10 mg/mL |
Storage | at -20°C |
Critical role of the proton-dependent oligopeptide transporter (POT) in the cellular uptake of the peptidyl nucleoside antibiotic, blasticidin S.
Kitamura K, et al. Biochim Biophys Acta Mol Cell Res. 2017 Feb;1864(2):393-398. PMID: 27916534.
Crystal and molecular structure of the antibiotic blasticidin S hydrochloride pentahydrate.
Swaminathan V, et al. Biochim Biophys Acta. 1981 Oct 27;655(3):335-41. PMID: 7284390.
Related Anti-infection Products |
---|
AMY-101 acetate
AMY-101 acetate is a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM). |
Amodiaquine
Amodiaquine is a 4-aminoquinoline compound related to chloroquine, used as an antimalarial and anti-inflammatory agent. |
Lysozyme (from egg white)
Lysozyme (from egg white) is a bactericidal enzyme present in chicken eggs, and it lyses gram-positive bacteria. |
Phe-Arg-β-naphthylamide 2HCl
Phe-Arg-β-naphthylamide 2HCl is an efflux pump inhibitor (EPI), it acts on the major multidrug resistance efflux transporters of Gram-negative bacteria. |
Allicin
Allicin has highly potent antimicrobial activity, and inhibits growth of a variety of microorganisms, among them antibiotic-resistant strains. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.