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BIX-01294

Cat. No. M8989
BIX-01294 Structure
Size Price Availability Quantity
10mg USD 145 In stock
50mg USD 490 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

BIX-01294 is an inhibitor of G9a Histone Methyltransferase with IC50 of 1.9 μM. BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264.7 cells. BIX01294 enhances the cardiac potential of bone marrow cells. BIX-01294 (5 µM) reduces levels of global H3K9 methylation in pronuclear- and 2-cell-stage embryos. BIX-01294 (1 µg/mL) causes reduction in the BrdU incorporation of fetal PASMCs. BIX-01294 treatment decreases the PASMCs migration induced by PDGF.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 490.64
Formula C28H38N6O2
CAS Number 935693-62-2
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
References

Modulation of microRNA expression in human lung cancer cells by the G9a histone methyltransferase inhibitor BIX01294.
Pang AL, et al. Oncol Lett. 2014 Jun;7(6):1819-1825. PMID: 24932239.

BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264.7 cells.
Tsuda H, et al. Bosn J Basic Med Sci. 2013 Nov;13(4):271-5. PMID: 24289765.

The histone methyltransferase inhibitor BIX01294 enhances the cardiac potential of bone marrow cells.
Mezentseva NV, et al. Stem Cells Dev. 2013 Feb 15;22(4):654-67. PMID: 22994322.

BIX-01294 treatment blocks cell proliferation, migration and contractility in ovine foetal pulmonary arterial smooth muscle cells.
Yang Q, et al. Cell Prolif. 2012 Aug;45(4):335-44. PMID: 22691107.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BIX-01294 supplier, Histone Methyltransferase, inhibitors

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