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BIBX 1382

Cat. No. M4805
BIBX 1382 Structure
Size Price Availability Quantity
5mg USD 130 In stock
10mg USD 220 In stock
50mg USD 740 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

BIBX 1382 is a new selective EGFR kinase inhibitor that do not block the activity of other tyrosine kinases.Tumor growth inhibition by BIBX1382 coincided with reduced pEGFR and Ki-67 levels in vivo, which is in accordance with the expected effect of EGFR inhibitors.BIBX1382 was an epidermal growth factor receptor inhibitor under clinical investigation for treatment of cancer.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 387.84
Formula C18H19ClFN7
CAS Number 196612-93-8
Purity >99%
Solubility DMSO ≥50 mg/mL
Water ≥50 mg/mL
Storage at -20°C

Cynomolgus monkey as a surrogate for human aldehyde oxidase metabolism of the EGFR inhibitor BIBX1382.
Hutzler JM, et al. Drug Metab Dispos. 2014 Oct;42(10):1751-60. PMID: 25035284.

Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives.
Solca FF, et al. J Pharmacol Exp Ther. 2004 Nov;311(2):502-9. PMID: 15199094.


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Abmole Inhibitor Catalog 2017

Keywords: BIBX 1382 supplier, EGFR/HER2, inhibitors

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