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BI-7273

Cat. No. M8931
BI-7273 Structure
Size Price Availability Quantity
10mg USD 200 In stock
50mg USD 600 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

BI-7273 is a potent and selective BRD9 inhibitor with IC50s of 19 nM and 117 nM for BRD9 and BRD7, respectively. BI-7273 blocks EOL-1 cell proliferation with EC50 of 1400 nM. In vitro, BI-7273 (1 μM) is active in U2OS cell lines.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Female BomTac:NMRI-Foxn1nu mice
Formulation 0.5% Natrosol
Dosages 20 and 180 mg/kg
Administration p.o.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 353.41
Formula C20H23N3O3
CAS Number 1883429-21-7
Purity >99%
Solubility DMSO: ≥ 40 mg/mL
Storage at -20°C
References

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor.
Martin LJ, et al. J Med Chem. 2016 May 26;59(10):4462-75. PMID: 26914985.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BI-7273 supplier, Epigenetic Reader Domain, inhibitors

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