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Betaxolol

Cat. No. M5453
Betaxolol Structure
Synonym:

SL 75212

Size Price Availability Quantity
10mg USD 80 In stock
50mg USD 160 In stock
100mg USD 260 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 307.43
Formula C18H29NO3
CAS Number 63659-18-7
Purity >99%
Solubility 62 mg/mL in DMSO
Storage at -20°C
References

On-line coupling of Micro-Extraction by Packed Sorbent with Sequential Injection Chromatography system for direct extraction and determination of betaxolol in human urine.
Šrámková I, et al. Talanta. 2015 Oct 1;143:132-7. PMID: 26078140.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Betaxolol, SL 75212 supplier, Adrenergic Receptor, inhibitors

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