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Betaxolol

Cat. No. M5453
Betaxolol Structure
Synonym:

SL 75212

Size Price Availability Quantity
10mg USD 57  USD57 In stock
50mg USD 102  USD102 In stock
100mg USD 170  USD170 In stock
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Quality Control & Documentation
Biological Activity

Betaxolol is a selective beta1-adrenergic receptor inhibitor that lowers intraocular pressure by reducing intraocular fluid production and may be used in studies related to hypertension and glaucoma.

Chemical Information
Molecular Weight 307.43
Formula C18H29NO3
CAS Number 63659-18-7
Solubility (25°C) DMSO 62 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Šrámková I, et al. Talanta. On-line coupling of Micro-Extraction by Packed Sorbent with Sequential Injection Chromatography system for direct extraction and determination of betaxolol in human urine.

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Keywords: Betaxolol, SL 75212 supplier, Adrenergic Receptor, inhibitors, activators


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