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Betaxolol HCl

Cat. No. M5454
Betaxolol HCl Structure
Synonym:

SL 75212 HCl

Size Price Availability Quantity
10mg USD 60 In stock
50mg USD 140 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Betaxolol is a β1 adrenergic receptor blocker with IC50 of 6 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 343.89
Formula C18H29NO3.HCl
CAS Number 63659-19-8
Purity >98%
Solubility 69 mg/mL in DMSO
Storage at -20°C
References

Penetration of betaxolol HCL ionic suspension 0.25% and betaxolol HCL solution 0.50% into the aqueous humor.
Yalvac I, et al. Eur J Ophthalmol. 2007 May-Jun;17(3):368-71. PMID: 17534818.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Betaxolol HCl, SL 75212 HCl supplier, Androgen Receptor, inhibitors

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