β-Cyclodextrin affects the formation of isomerization products during peptide deamidation.
J Exp Med. 2017 May 1;214(5):1387-1409.
Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation
β-Cyclodextrin purchased from AbMole
|Source||J Exp Med (2017). Figure 3. Cyclodextrin (Abmole Bioscience)|
|Cell Lines||CD45-positive cells|
|Incubation Time||2 wk|
|Results||Atorvastatin was dissolved at a final concentration of 20 mg/ml in cyclodextrin (5 mg/m). The contribution of cholesterol and BA metabolism to the phenotype was next assessed using an inhibitor of the HMGCoA reductase (HMG CR) atorvastatin (in short, statin).|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Letter: β-Cyclodextrin affects the formation of isomerization products during peptide deamidation.
Volmer DA,et.al. Eur J Mass Spectrom (Chichester, Eng). 2015;701-5. PMID: 26353992.
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