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β-Cyclodextrin

Cat. No. M5083

β-Cyclodextrin Structure
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

β-Cyclodextrin affects the formation of isomerization products during peptide deamidation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 1134.98
Formula C42H70O35
CAS Number 7585-39-9
Purity >99%
Solubility DMSO
Storage at -20°C
Customer Product Validations & Biological Datas
Source J Exp Med (2017). Figure 3. Cyclodextrin (Abmole Bioscience)
Method proliferation assy
Cell Lines CD45-positive cells
Concentrations 5 mg/ml
Incubation Time 2 wk
Results Atorvastatin was dissolved at a final concentration of 20 mg/ml in cyclodextrin (5 mg/m). The contribution of cholesterol and BA metabolism to the phenotype was next assessed using an inhibitor of the HMGCoA reductase (HMG CR) atorvastatin (in short, statin).
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Product Citations
References

Letter: β-Cyclodextrin affects the formation of isomerization products during peptide deamidation.
Volmer DA,et.al. Eur J Mass Spectrom (Chichester, Eng). 2015;701-5. PMID: 26353992.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: β-Cyclodextrin supplier, inhibitors

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