β-Cyclodextrin affects the formation of isomerization products during peptide deamidation.
J Exp Med. 2017 May 1;214(5):1387-1409.
Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation
β-Cyclodextrin purchased from AbMole
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Source | J Exp Med (2017). Figure 3. Cyclodextrin (Abmole Bioscience) |
| Method | proliferation assy | |
| Cell Lines | CD45-positive cells | |
| Concentrations | 5 mg/ml | |
| Incubation Time | 2 wk | |
| Results | Atorvastatin was dissolved at a final concentration of 20 mg/ml in cyclodextrin (5 mg/m). The contribution of cholesterol and BA metabolism to the phenotype was next assessed using an inhibitor of the HMGCoA reductase (HMG CR) atorvastatin (in short, statin). |
| Molecular Weight | 1134.98 |
| Formula | C42H70O35 |
| CAS Number | 7585-39-9 |
| Form | Solid |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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