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Berberine chloride

Cat. No. M5000
Berberine chloride Structure
Size Price Availability Quantity
50mg USD 40  USD40 In stock
100mg USD 60  USD60 In stock
500mg USD 105  USD105 In stock
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Quality Control
Biological Activity

Treatment with BBR(Berberine) in rats on the atherogenic diet reduced plasma total cholesterol and nonHDL cholesterol levels by 29%-33% and 31%-41%, respectively, with no significant differences being observed among the three doses.Berberine induced both apoptotic and autophagic death of HepG2 cells, which was associated with a significant activation of AMPK and an increased expression of the inactive form of acetyl-CoA carboxylase (ACC).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 371.81
Formula C20H18ClNO4
CAS Number 633-65-8
Purity 99.8%
Solubility DMSO 10 mg/mL
Storage at -20°C
References

[1] Wang Y,et.al. Metabolism. Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption.

[2] Yu R,et.al. Cancer Cell Int. Berberine-induced apoptotic and autophagic death of HepG2 cells requires AMPK activation.

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