Benproperine phosphate is an orally active, potent inhibitor of actin-associated protein 2/3 complex subunit 2 (ARPC2) that attenuates the rate of actin polymerization by impairing the function of Arp2/3.Benproperine phosphate inhibits cancer cell migration and tumor metastasis and has been used in studies related to cough. Benproperine phosphate inhibits cancer cell migration and tumor metastasis and can be used in cough-related studies.
| Molecular Weight | 407.44 |
| Formula | C21H30NO5P |
| CAS Number | 19428-14-9 |
| Form | Solid |
| Solubility (25°C) | DMSO >100 mg/mL Water >100 mg/mL |
| Storage | 4°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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