BDS-I

Cat. No. M42240

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Quality Control & Documentation

Purity:
COA
MSDS

Product Information

Biological Activity

BDS-I known as blood depressing substance, is a marine toxin which can be extracted from Anemonia sulcata.

Chemical Information

Molecular Weight	4708.34
Formula	C210H297N57O56S6
CAS Number	207621-38-3
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B K_m
	Animal A K_m

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ilaria Piccialli et al. Toxins (Basel). The Anemonia sulcata Toxin BDS-I Protects Astrocytes Exposed to Aβ1-42 Oligomers by Restoring [Ca2+]i Transients and ER Ca2+ Signaling

[2] Maurizio Turzo et al. BMC Pulm Med. Inhibition of overexpressed Kv3.4 augments HPV in endotoxemic mice

[3] Ilaria Piccialli et al. Neural Regen Res. The new KV3.4 inhibitor BDS-I[1-8] as a potential pharmacological opportunity in Alzheimer's disease therapy

[4] Roselia Ciccone et al. Front Chem. Synthesis and Pharmacological Evaluation of a Novel Peptide Based on Anemonia sulcata BDS-I Toxin as a New KV3.4 Inhibitor Exerting a Neuroprotective Effect Against Amyloid-β Peptide

[5] Pin Liu et al. J Neurophysiol. Modulation of neuronal sodium channels by the sea anemone peptide BDS-I

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Signaling Pathways

BDS-I

Quality Control & Documentation

Biological Activity

Chemical Information

Conversion of different model animals based on BSA (PMID: 27057123)

References

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