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Bay 11-7085

Cat. No. M2435

Bay 11-7085 Structure

Synonym: Bay 11-7083

Size Price Availability Quantity
10mg USD 70 In stock
25mg USD 150 In stock
50mg USD 270 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM.

Protocol
Cell Experiment
Cell lines HUVEC
Preparation method Human umbilical vein endothelial cells (HUVEC) were isolated and maintained in culture using previously described procedures. For experiments on cytokine induction, cells were exposed to recombinant human TNFα at a final concentration of 100 units/ml in complete media for the times indicated. The proteosomal inhibitor carbobenzoxyl-leucinyl-leucinyl-leucinal-H (MG115) was prepared as a 40 mM stock solution in Me2SO and added to complete medium to a final concentration of 40 μM. Cell toxicity was assessed by morphology and by 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay.
Concentrations 0, 1.25, 2.5, 5, 10 and 20 μM
Incubation time 16 h
Animal Experiment
Animal models male Lewis rats of Adjuvant Arthritis model
Formulation 0.5% methyl cellulose
Dosages 5 or 20 mg/kg once a day
Administration intraperitoneal injection
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 249.33
Formula C13H15NO2S
CAS Number 196309-76-9
Purity >99%
Solubility DMSO 40 mg/mL
Storage at -20°C
References

Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo.
Pierce JW, et al. J Biol Chem. 1997 Aug 22;272(34):21096-103. PMID: 9261113.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Bay 11-7085, Bay 11-7083 supplier, IκB/IKK, inhibitors

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