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Basmisanil

Cat. No. M6245
Basmisanil  Structure
Synonym:

RG1662; RO5186582

Size Price Availability Quantity
5mg USD 420 In stock
10mg USD 660 In stock
50mg USD 1900 In stock
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Quality Control
  • Current batch:
  • Purity > 99%
  • COA
  • MSDS
Biological Activity

Basmisanil is a highly selective GABAAα5 negative allosteric modulator.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 445.46
Formula C21H20FN3O5S
CAS Number 1159600-41-5
Purity > 99%
Solubility 32 mg/mL in DMSO
Storage at -20°C
References

Characterising Drug Release from Immediate-Release Formulations of a Poorly Soluble Compound, Basmisanil, Through Absorption Modelling and Dissolution Testing.
Stillhart C, et al. AAPS J. 2017 May;19(3):827-836. PMID: 28236228.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Basmisanil , RG1662; RO5186582 supplier, inhibitors

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