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Barbacarpan

Cat. No. M17307
Barbacarpan Structure
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Biological Activity

Barbacarpan

Chemical Information
CAS Number 213912-46-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Natalia Caproş, et al. Rev Med Chir Soc Med Nat Iasi. Aspects of the molecular-genetic profile in patients with ischemic heart disease

[2] N Sirocova, et al. Haemophilia. Factor VIII mutations in 42 Moldovan haemophilia A families, including 12 that are novel

[3] I Negrutiu, et al. Plant Physiol. Dioecious plants. A key to the early events of sex chromosome evolution

[4] C Delichre, et al. EMBO J. SlY1, the first active gene cloned from a plant Y chromosome, encodes a WD-repeat protein

[5] N Barbacar, et al. Plant J. Isolation of early genes expressed in reproductive organs of the dioecious white campion (Silene latifolia) by subtraction cloning using an asexual mutant

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