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Baicalein

Cat. No. M6098
Baicalein Structure
Synonym:

5,6,7-Trihydroxyflavone

Size Price Availability Quantity
100mg USD 80 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

In vitro: Baicalein suppresses mitogen induced T cell proliferation and cytokine secretion in vitro. Pre-treatment with baicalein significantly suppresses Con A or anti-CD3/CD28 mAb induced proliferation as well as cytokine secretion at 25 μM. Baicalein treatment induces DNA binding of NF-κB but inhibits thioredoxin activity in the nuclear compartment. Baicalein suppresses proliferation, migration, and invasion of MDA-MB-231 cells in a time- and dose-dependent manner. Baicalein significantly decreases the expression of SATB1 in MDA-MB-231 cells. Baicalein also downregulates the expression of Wnt1 and β-catenin proteins and transcription level of Wnt/β-catenin-targeted genes. In vivo: Baicalein suppresses induction of graft versus host disease but does not inhibit homeostatic proliferation of T-cells in mice. This observation clearly shows potent anti-inflammatory activity of baicalein in vivo. Rats treated with baicalein are protected against an increase in heart to body weight ratio, plasma level of brain natriuretic peptides, intraventricular septum thickness, myocardial collagen volume of left ventricle (all P<0.05, respectively). The antifibrotic effects of baicalein are further illustrated by the suppressed expression of left ventricle pro-collagens I and III accompanied by the decreased expression of 12-lipoxygenase, and by reduced expression and activity of matrix metallopeptidase 9 and extracellular signal-regulated kinases. Baicalein can inhibit cardiac fibrosis in hypertensive rats.

Protocol
Cell Experiment
Cell lines MDA-MB-231 cells
Preparation method MDA-MB-231 cells are routinely digested, collected, and then seeded in 96-well plates at a density of 8×10^3 cells/well. After incubation for 12-24 hours, cells are treated with 0, 20, 40, 60, 80, 100, and 120 μM baicalein according to their experimental grouping and then incubated at 37°C for 24, 48, and 72 hours
Concentrations 0, 20, 40, 60, 80, 100, and 120 μM
Incubation time 12-24 h
Animal Experiment
Animal models C57BL/6 mice
Formulation
Dosages 100mg/kg,
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 270.24
Formula C15H10O5
CAS Number 491-67-8
Purity >98%
Solubility 54 mg/mL in DMSO
Storage at -20°C
References

Colon cancer chemopreventive effects of baicalein, an active enteric microbiome metabolite from baicalin.
Wang CZ, et al. Int J Oncol. 2015 Nov;47(5):1749-58. PMID: 26398706.

Baicalein protects against polymicrobial sepsis-induced liver injury via inhibition of inflammation and apoptosis in mice.
Liu A, et al. Eur J Pharmacol. 2015 Feb 5;748:45-53. PMID: 25533331.

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  Catalog
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Keywords: Baicalein, 5,6,7-Trihydroxyflavone supplier, inhibitors

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