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Azimilide

Cat. No. M5437
Azimilide Structure
Synonym:

NE-10064

Size Price Availability Quantity
5mg USD 60 In stock
10mg USD 110 In stock
50mg USD 440 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Azimilide(NE-10064) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 457.95
Formula C23H28ClN5O3
CAS Number 149908-53-2
Purity >98%
Solubility 10mM in DMSO
Storage at -20°C
References

CPUY11018, an azimilide derivative, ameliorates isoproterenol-induced cardiac insufficiency through relieving dysfunctional mitochondria and endoplasmic reticulum.
Li M, et al, J Pharm Pharmacol. 2015 Aug;67(8):1029-41. PMID: 25828246.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Azimilide, NE-10064 supplier, Potassium Channel, inhibitors

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