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Azilsartan medoxomil

Cat. No. M2105
Azilsartan medoxomil Structure
Synonym:

TAK-491

Size Price Availability Quantity
25mg USD 120 In stock
50mg USD 840 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Azilsartan medoxomil is an orally administered angiotensin II receptor type 1 antagonist (blocker) used in the treatment of adults with essential hypertension. In vitro, azilsartan produced greater and more sustained AT(1) receptor binding/blockade activity than several comparator angiotensin II receptor antagonists. Azilsartan medoxomil reduces blood pressure (BP) in hypertensive adults. In adults with essential hypertension, azilsartan medoxomil 20, 40 or 80 mg effectively reduced BP over a 24-hour period with once-daily administration in three major, randomized, controlled trials in which the primary endpoints were changes from baseline in 24-hour mean systolic BP (SBP) at week 6 (two trials) or week 24, assessed by ambulatory BP monitoring (ABPM).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 568.53
Formula C30H24N4O8
CAS Number 863031-21-4
Purity >99%
Solubility DMSO 100 mg/mL
Storage at -20°C
References

Azilsartan medoxomil: a review of its use in hypertension.
Perry CM. Clin Drug Investig. 2012 Sep 1;32(9):621-39. PMID: 22877322.

Azilsartan medoxomil plus chlorthalidone reduces blood pressure more effectively than olmesartan plus hydrochlorothiazide in stage 2 systolic hypertension.
Cushman WC, et al. Hypertension. 2012 Aug;60(2):310-8. PMID: 22710649.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Azilsartan medoxomil, TAK-491 supplier, Angiotensin Receptor, inhibitors

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