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AZD-7325 is a GABA-Aα2,3 -selective receptor modulator.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Molecular Weight | 354.38 |
| Formula | C19H19FN4O2 |
| CAS Number | 942437-37-8 |
| Purity | >98% |
| Solubility | DMSO 10 mM |
| Storage | at -20°C |
The effects of the nonselective benzodiazepine lorazepam and the α2 /α3 subunit-selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levels.
Te Beek ET, et al. Clin Pha rmacol Dru gDev. 2015 Mar;4(2):149-54. PMID: 27128218.
The central nervous system effects of the partial GABA-Aα2,3 -selective receptor modulator AZD7325 in comparison with lorazepam in healthy males.
Chen X, et al. Br J Clin Pharmacol. 2014 Dec;78(6):1298-314. PMID: 24802722.
A clinical study to assess CYP1A2 and CYP3A4 induction by AZD7325, a selective GABA(A) receptor modulator - an in vitro and in vivo comparison.
Zhou D, et al. Br J Clin Pharmacol. 2012 Jul;74(1):98-108. PMID: 22122233.
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