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AZD-7325

Cat. No. M9411
AZD-7325 Structure
Synonym:

AZD7325

Size Price Availability Quantity
10mg USD 390 In stock
25mg USD 760 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

AZD-7325 is a GABA-Aα2,3 -selective receptor modulator.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 354.38
Formula C19H19FN4O2
CAS Number 942437-37-8
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
References

The effects of the nonselective benzodiazepine lorazepam and the α2 /α3 subunit-selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levels.
Te Beek ET, et al. Clin Pha rmacol Dru gDev. 2015 Mar;4(2):149-54. PMID: 27128218.

The central nervous system effects of the partial GABA-Aα2,3 -selective receptor modulator AZD7325 in comparison with lorazepam in healthy males.
Chen X, et al. Br J Clin Pharmacol. 2014 Dec;78(6):1298-314. PMID: 24802722.

A clinical study to assess CYP1A2 and CYP3A4 induction by AZD7325, a selective GABA(A) receptor modulator - an in vitro and in vivo comparison.
Zhou D, et al. Br J Clin Pharmacol. 2012 Jul;74(1):98-108. PMID: 22122233.

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