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Azatadine dimaleate

Cat. No. M2416
Azatadine dimaleate Structure

Azatadine maleate

Size Price Availability Quantity
50mg USD 190 In stock
200mg USD 300 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Azatadine is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively. Azatadine puts back the onset of dyspnea-induced by aerosolized histamine, acetylcholine and serotonin in the conscious guinea-pig with PD50 of 0.01 mg/kg, 0.739 mg/kg and 0.86 mg/kg. It protects conscious guinea-pigs against death induced by the intravenous injection of histamine with oral PD50 of 0.009 mg/kg in guinea-pig and 0.22 mg/kg in mice. Azatadine (1 mg twice daily for 14 days) is effective in relieving the histamine-mediated symptoms of seasonal allergic rhinitis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 522.55
Formula C20H22N2.2C4H4O4
CAS Number 3978-86-7
Purity >98%
Solubility DMSO 90 mg/mL
Storage at -20°C

The pharmacology of azatadine, a potential antiallergy drug.
Tozzi S,et al. Agents Actions. 1974 Oct;4(4):264-70. PMID: 4155594.

Comparative effects of loratadine and azatadine in the treatment of seasonal allergic rhinitis.
Katelaris C. Asian Pac J Allergy Immunol. 1990 Dec;8(2):103-7. PMID: 1982614.

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Keywords: Azatadine dimaleate, Azatadine maleate supplier, Histamine Receptor, inhibitors

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