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Cat. No. M2411
AXL1717 Structure

CAS# 17434-18-3

Size Price Availability Quantity
10mM/1mL In DMSO USD 100 In stock
10mg USD 90 In stock
50mg USD 320 In stock
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Quality Control
Biological Activity

AXL1717 (picropodophyllin, Picropodophyllotoxin, PPP) is a non-competitive, potent, and specific inhibitor of IGF-1Rα/β with IC50 of 1 nM. It exhibits little effect towards IR, FGFR, PDGFR and EGFR, and exerts no effects on microtubules and DNA topoisomerase II. Picropodophyllotoxin inhibits IGF1R autophosphorylation (IC50 ~ 1 nM), increases the fraction of cells in the G2/M phase and upregulates apoptosis.It also exhibits antiproliferative effects in multiple cancer cell lines (IC50 = 0.05 - 15 μM). In vivo,it has anticancer and antineovascularization activity. 

Another CAS# 17434-18-3

Customer Product Validations & Biological Datas
Source Cancer Sci (2018). Figure 4. AXL1717
Method MTT assay
Cell Lines MKN7 cells
Concentrations 500 nmol/L
Incubation Time 3 days
Results The cell proliferation ratios of the cells treated with afatinib, neratinib, or PPP compared with a control were 62.3%, 45.9%, and 54.1%, respectively.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 414.41
Formula C22H22O8
CAS Number 477-47-4
Purity >99%
Solubility DMSO
Storage at -20°C

Potent inhibitory effect of the cyclolignan picropodophyllin (PPP) on human adrenocortical carcinoma cells proliferation.
Doghman M, et al. Am J Cancer Res. 2011;1(3):356-361. PMID: 21968616.

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Abmole Inhibitor Catalog 2017

Keywords: AXL1717, CAS# 17434-18-3 supplier, IGF-1R, inhibitors

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