Catalog

IGF-1R Insulin-like Growth Factor-1 Receptor

Inhibitors

Cat.No.	Name	Information
M3744	NVP-AEW541	NVP-AEW541 is a novel, potent and selective inhibitor of IGF-IR kinase with IC50 value of 0.086.
M3397	AG-1024	AG-1024 (Tyrphostin) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, is less potent to IR with IC50 of 57 μM and specifically distinguishes between InsR and IGF-1R (as compared to other tyrphostins).
M2411	AXL1717	AXL1717 (picropodophyllin, Picropodophyllotoxin, PPP) is a non-competitive, potent, and specific inhibitor of IGF-1Rα/β with IC50 of 1 nM.
M2192	BMS-754807	BMS-754807 is an ATP-competitive dual-kinase inhibitor of IGF-1R and IR with IC50s of 1.8 nM and 1.7 nM, respectively.
M2025	PQ401	PQ401 is an insulin growth factor-1 receptor (IGF-1R) inhibitor.
M1957	BMS-536924	BMS-536924 is an ATP-competitive IGF-IR and IR inhibitor with IC50 of 100 nM and 73 nM respectively.
M1821	OSI-906	OSI-906 (Linsitinib) is a potent, selective, dual ATP-competitive tyrosine kinase inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) with IC50 values of 35 nM and 75 nM respectively.
M1792	XL228	XL228 is a potent multikinase small-molecule inhibitor of insulin-like growth factor type 1 receptor (IGF1R).
M1717	GSK1904529A	GSK1904529A selectively inhibits IGF-IR and IR with IC50s of 27 and 25 nmol/L, respectively.