Inhibitors
Cat.No. | Name | Information |
---|---|---|
M8829 | Picropodophyllotoxin | Picropodophyllotoxin is an insulin-like growth factor-I (IGF-I) receptor kinase inhibitor. |
M3744 | NVP-AEW541 | NVP-AEW541 is a novel, potent and selective inhibitor of IGF-IR kinase with IC50 value of 0.086. |
M3397 | AG-1024 | AG-1024 (Tyrphostin) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, is less potent to IR with IC50 of 57 μM and specifically distinguishes between InsR and IGF-1R (as compared to other tyrphostins). |
M2411 | AXL1717 | AXL1717 (picropodophyllin, Picropodophyllotoxin, PPP) is a non-competitive, potent, and specific inhibitor of IGF-1Rα/β with IC50 of 1 nM. |
M2192 | BMS-754807 | BMS-754807 is an ATP-competitive dual-kinase inhibitor of IGF-1R and IR with IC50s of 1.8 nM and 1.7 nM, respectively. |
M2025 | PQ401 | PQ401 is an insulin growth factor-1 receptor (IGF-1R) inhibitor. |
M1957 | BMS-536924 | BMS-536924 is an ATP-competitive IGF-IR and IR inhibitor with IC50 of 100 nM and 73 nM respectively. |
M1821 | OSI-906 | OSI-906 (Linsitinib) is a potent, selective, dual ATP-competitive tyrosine kinase inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) with IC50 values of 35 nM and 75 nM respectively. |
M1792 | XL228 | XL228 is a potent multikinase small-molecule inhibitor of insulin-like growth factor type 1 receptor (IGF1R). |
M1717 | GSK1904529A | GSK1904529A selectively inhibits IGF-IR and IR with IC50s of 27 and 25 nmol/L, respectively. |
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