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  Catalog
Abmole Inhibitor Catalog 2017

IGF-1R Insulin-like Growth Factor-1 Receptor

Inhibitors

Cat.No.  Name Information
M3744 NVP-AEW541 NVP-AEW541 is a novel, potent and selective inhibitor of IGF-IR kinase with IC50 value of 0.086.
M3397 AG-1024 AG-1024 (Tyrphostin) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, is less potent to IR with IC50 of 57 μM and specifically distinguishes between InsR and IGF-1R (as compared to other tyrphostins).
M2411 AXL1717 AXL1717 (picropodophyllin, Picropodophyllotoxin, PPP) is a non-competitive, potent, and specific inhibitor of IGF-1Rα/β with IC50 of 1 nM.
M2192 BMS-754807 BMS-754807 is an ATP-competitive dual-kinase inhibitor of IGF-1R and IR with IC50s of 1.8 nM and 1.7 nM, respectively.
M2025 PQ401 PQ401 is an insulin growth factor-1 receptor (IGF-1R) inhibitor.
M1957 BMS-536924 BMS-536924 is an ATP-competitive IGF-IR and IR inhibitor with IC50 of 100 nM and 73 nM respectively.
M1821 OSI-906 OSI-906 (Linsitinib) is a potent, selective, dual ATP-competitive tyrosine kinase inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) with IC50 values of 35 nM and 75 nM respectively.
M1792 XL228 XL228 is a potent multikinase small-molecule inhibitor of insulin-like growth factor type 1 receptor (IGF1R).
M1717 GSK1904529A GSK1904529A selectively inhibits IGF-IR and IR with IC50s of 27 and 25 nmol/L, respectively.


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