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Axillarin

Cat. No. M16803
Axillarin Structure
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Biological Activity

Axillarin

Chemical Information
CAS Number 5188-73-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] S Muhammad, et al. Braz J Biol. A threefold approach including quantum chemical, molecular docking and molecular dynamic studies to explore the natural compounds from Centaurea jacea as the potential inhibitors for COVID-19

[2] Katarzyna Gaweł-Bęben, et al. Molecules. Achillea millefolium L. and Achillea biebersteinii Afan. Hydroglycolic Extracts-Bioactive Ingredients for Cosmetic Use

[3] Eltayeb Fadul, et al. Nat Prod Res. Anti-glycating and anti-oxidant compounds from traditionally used anti-diabetic plant Geigeria alata(DC) Oliv. & Hiern

[4] Valeria Moscatelli, et al. Planta Med. Flavonoids from Artemisia copa with anti-inflammatory activity

[5] So Ra Kim, et al. Free Radic Biol Med. Flavonoids of Inula britannica protect cultured cortical cells from necrotic cell death induced by glutamate

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