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Auraptene is an estrogen receptor modulator that also acts as an ACAT inhibitor. It displays anti-tumor effects in several xenograft and chemically-induced murine tumor models. Auraptene induces apoptosis and is anti-proliferative in cancer cell lines. It has agonistic properties against PPARs, and interferes with lipid and cholesterol production by inhibiting ACAT (IC50 = 4 uM).
| Molecular Weight | 298.38 |
| Formula | C19H22O3 |
| CAS Number | 495-02-3 |
| Solubility (25°C) | DMSO: ≥20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Zahra Tayarani-Najaran, et al. A Review of Auraptene as an Anticancer Agent
[3] Mohammad Reza Shiran, et al. Antitumor effects of Auraptene in 4T1 tumor-bearing Balb/c mice
[4] Bahram Bibak, et al. A review of the pharmacological and therapeutic effects of auraptene
[5] Giuseppe Derosa, et al. Auraptene and Its Role in Chronic Diseases
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